Colostrum Article in the American Journal of Natural Medicine

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Bovine Colostrum as an Immune System Modulator

Source: American Journal of Natural Medicine, March 1998, by Zoltan Rona, M.D.

Introduction

Over the last couple of years, healthcare practitioners have been hearing a great deal about bovine colostrum, a relatively new food supplement intended to optimize the immune systems of both healthy and chronically ill individuals. Much of the enthusiasm surrounding colostrum has come from testimonials, anecdotal reports, and the marketing efforts of several new supplement manufacturers and distributors. The past 20 years have also seen the publication of more than 2,000 research papers strongly supporting colostrum and its many components. This paper reviews the scientific evidence for the clinical application of a promising immune system modulator.

In “Colostrum, Life’s First Food,” Dr. Daniel G. Clark’s central message, as printed on the back cover of his book, is that bovine colostrum “Rebuilds the immune system, destroys viruses, bacteria and fungi, accelerates healing of all body tissue, helps lose weight, burn fat, increase bone and lean muscle mass and slows down and even reverses aging.” According to Clark and the well-known naturopathic physician Dr. Bernard Jensen, colostrum has a therapeutic role to play in AIDS, cancer, heart disease, diabetes, autoimmune diseases, allergies, herpes, bacterial, viral and parasitic infections, gingivitis, colds, the flu and much more. Colostrum has antioxidant properties, is anti-inflammatory, and is a source of many vitamins, minerals, enzymes and amino acids.

Colostrum Rediscovered

Historically, Ayurvedic physicians have used bovine colostrum therapeutically in India for thousands of years. In the US and throughout the world, conventional doctors used it for antibiotic purposes prior to the introduction of sulfa drugs and penicillin. In the early 1950s, colostrum was prescribed extensively for the treatment of rheumatoid arthritis. In 1950, Dr. Albert Sabin, the polio vaccine developer, discovered that colostrum contained antibodies against polio and recommended it for children susceptible to catching polio.

What is Colostrum?

Colostrum is the first mammary secretion that a mammal provides for its newborn during the first 24–48 hours. It contains numerous immune system and growth factors as well as essential nutrients, trypsin and protease inhibitors that protect it from destruction in the GI tract. It is estimated that colostrum triggers at least fifty processes in the newborn. Bovine colostrum is biologically transferable to all mammals, including man, and is much higher in immune factors than human mother’s colostrum. Laboratory analyses of immune and growth factors from bovine colostrum are identical to those found in human colostrum except that the levels of these factors are significantly higher in the bovine version. For example, human colostrum contains 2% of IgG while cow colostrum contains 86% of IgG, the most important of the immunoglobulins found in the body. Bovine colostrum contains a blocking hormone to prevent the calf from becoming sensitized to its own mother’s immune factors. Studies indicate that all species, including man, benefit from the immune boosting properties of bovine colostrum with no reports of allergic or anaphylactic reactions to date. It is in a very limited supply because colostrum is only available for a day or two after calving. The needs of the newborn calf must be met first and only high quality colostrum is taken from cows that have been certified free of antibiotics, pesticides and synthetic hormones. Colostrum must be processed at low temperatures so that the immune and growth factors remain biologically viable.

Major Colostrum Components

The most important components of colostrum can basically be broken down into two major categories: immune system factors and growth factors. Drug manufacturers have tried to copy (genetically engineer) and market several of the individual components of colostrum, most notably interferon, gamma globulin, growth hormone, IgF-1 and protease inhibitors. Biotechnology companies are currently selling IgF-1 for as much as $800 per 50 cc vial. Some of the following colostrum components may very well be next on the list of “major breakthroughs” by the pharmaceutical/nutraceutical industry:

  • Immunoglobulins (A, D, E, G and M) – the most abundant of the immune factors found in colostrum; IgG neutralizes toxins and microbes in the lymph and circulatory system; IgM destroys bacteria while IgE and IgD are highly antiviral.
  • Lactoferrin – an antiviral, anti-bacterial, anti-inflammatory, iron-binding protein with therapeutic effects in cancer, HIV, Cytomegalovirus, herpes, Chronic Fatigue Syndrome, Candida albicans and other infections. Lactoferrin helps deprive bacteria of the iron they require to reproduce and releases iron into the red blood cells enhancing oxygenation of tissues. Lactoferrin modulates cytokine release and its receptors have been found on most immune cells including lymphocytes, monocytes, macrophages and platelets.
  • Proline-Rich Polypeptide (PRP) – a hormone that regulates the thymus gland, stimulating an underactive immune system or down-regulating an overactive immune system as seen in autoimmune disease (MS, rheumatoid arthritis, lupus, scleroderma, chronic fatigue syndrome, allergies, etc.).

Growth Factors

  • Epithelial growth factor (EgF)
  • Insulin-like growth factor-I and II (IGF-1 and IGF-II)
  • Fibroblast growth factor (FgF)
  • Platelet-derived growth factor (PDGF)
  • Transforming growth factors A & B (TgA and B)
  • Growth hormone (GH)

These all help stimulate cell and tissue growth by stimulating DNA formation. Genetically engineered versions of IGF-1 and GH are now marketed as anti-aging and AIDS drugs. They are found naturally and in high concentrations in colostrum. Several studies show that these growth factors are capable of increasing T-cell production, accelerate healing, balance blood glucose, reduce insulin need, increase muscle and bone growth and repair while metabolizing fat for fuel.

A 1990 study in the New England Journal of Medicine concluded that GH treatment prevented some of the signs of aging. In his study, Dr. Daniel Rudman treated 26 men between the ages of 61–80 with GH. Patients experienced a decrease in overall body fat (of up to 14%), an increase in bone density and lean muscle mass. In addition, their skin was thicker and more elastic. Rudman said the changes were equivalent to those incurred over a 10–20 year period of aging.

  • Leukocytes – stimulate the production of interferon, which slows viral reproduction, and penetration of cell walls.
  • Enzymes – lactoperoxidase-thiocyanate, peroxidase and xanthine oxidase oxidize bacteria through their ability to release hydrogen peroxide.
  • Lysozyme – a hydrolyzing agent and immune system booster capable of destroying bacteria and viruses on contact.
  • Cytokines – interleukins that regulate the duration and intensity of the immune response.

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