|Allergies||Autoimmunity||Healing||Pain and Fibromyalgia|
|Alzheimer’s||Body Building||Immunity||Weight Loss|
|Athletics||Digestive Tract Disorders||Lupus|
Allergies and Autoimmunity
Immunomodulatory proteins in colostrum
Plusa T: Department of Internal Medicine, Pneumonology and Allergology, Central Clinical Hospital of the Ministry of National Defense, Military Institute of Health Services in Warsaw, Poland. firstname.lastname@example.org: 2009 Mar;26(153):234-8.
The value of bovine colostrums is documented in clinical observations and supported by large database. An antibacterial effect and modulation of the immune response are accepted. The wide spectrum of the activity of a lactoferrin or a proline-rich polipeptide complex was confirmed in experimental and clinical studies. Moreover, a high concentration of immunoglobulins in bovine colostrum gives exceptional opportunity for use as a support in immunodeficiency treatment.
PMID: 19388540 [PubMed – indexed for MEDLINE]
Identification and quantification of innate immune system mediators in human breast milk.
Allergy Asthma Proc. 2004 Sep-Oct;25(5):297-304.; Armogida SA, Yannaras NM, Melton AL, Srivastava MD; Department of Allergy and Immunology, Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland, OH 44195, USA.
Colostrum and bioactive, colostral peptides differentially modulate the innate immune response of intestinal epithelial cells.
J Pept Sci. 2010 Jan;16(1):21-30.Department of Food Science, Aarhus University, Blichers Allé 20, DK-8830 Tjele, Denmark; Jørgensen AL, Juul-Madsen HR, Stagsted J.
Potential immunoregulatory role of heme oxygenase-1 in human milk: a combined biochemical and molecular modeling approach.
Department of Biological Chemistry, Medical Chemistry and Molecular Biology, University of Catania, 95125 Catania, Italy; Li Volti G, Galvano F, Frigiola A, Guccione S,Di Giacomo C, Forte S, Tringali G, Caruso M, Adekoya OA, Gazzolo D.
PMID: 19879747 [PubMed – as supplied by publisher]
Cytokines in human milk.
Res Commun Mol Pathol Pharmacol. 1996 Sep;93(3):259-62. Srivastava MD,Srivastava A, Brouhard B, Saneto R, Groh-Wargo S, Kubit J;
Department of Pediatrics, Cleveland Clinic Foundation, OH 44195, USA.
Colostral Proline-Rich Polypeptides – Immunoregulatory Properties and Prospects of Therapeutic Use in Alzheimer’s Disease.
Curr Alzheimer Res. 2009 Nov 26; Janusz M, Zablocka A.; Department of Immunochemistry, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 R.Weigla, 53-114 Wroclaw, Poland. email@example.com.
>PMID: 19939229 [PubMed – as supplied by publisher]
The protective effects of the nutraceutical, colostrinin, against Alzheimer’s disease, is mediated via prevention of apoptosis in human neurones induced by aggregated beta-amyloid.
J Nutr Health Aging. 2009 Jun;13(6):522-7.Douraghi-Zadeh D, Matharu B, Razvi A, Austen B.; Neurodegeneration Unit, Basic Medical Sciences, St. George’s, University of London, Cranmer Terrace, Tooting, London, UK.
PMID: 19536420 [PubMed – indexed for MEDLINE]
A proline-rich polypeptide complex (PRP) isolated from ovine colostrum. Modulation of H2O2 and cytokine induction in human leukocytes
Department of Immunochemistry, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 R. Weigla, 53-114 Wroclaw, Poland; Agnieszka Zablocka, Maria Janusz, , Józefa Macalaa and Józef Lisowskia
Abstract: A proline-rich polypeptide complex (PRP) has immunoregulatory properties and also shows beneficial effects in Alzheimer’s disease (AD). It is known that the unregulated activation of microglial cells in AD may result in chronic inflammatory response. There is a link between the activation of immune cells on the periphery and in the central nervous system (CNS). Therefore, we studied the effect of the PRP on human peripheral blood mononuclear cells (PBMCs) stimulated by LPS with PHA (LP) or PMA as proinflammatory activators. PRP and its nonapeptide fragment (NP) inhibited by 40–60% production of H2O2 induced by PMA. The peptides also inhibited activity of superoxide dismutase. Both peptide preparations showed differential effects on the secretion of cytokines. NP induced TNF-α only while PRP induced IL-6, IL-10 and TNF-α. On the other hand, the release of TNF-α and IL-10 induced by LP in PBMCs was inhibited by PRP while NP inhibited the release of IFN-γ and IL-10. The results obtained showed that PRP may affect not only adaptive immunity but also innate immunity and thus may regulate secretions of mediators of inflammation. The regulatory effect of the PRP on the innate immunity may shed some light on understanding the beneficial effects of this polypeptide complex in AD patients.
Antioxidant and radical scavenging activity of human colostrum, transitional and mature milk.
J Clin Biochem Nutr. 2009 Sep;45(2):150-4. Epub 2009 Aug 28.Zarban A, Taheri F, Chahkandi T,Sharifzadeh G, Khorashadizadeh M.; Biochemistry department, Faculty of Medicine, Birjand University of Medical Sciences, Birjand 9717853577, Iran.
Antioxidants in colostrum and milk of sows and cows.
Reprod Domest Anim. 2009 Aug;44(4):606-11.; Albera E, Kankofer M.; Department of Animal Biochemistry and Physiology, Faculty of Veterinary Medicine, Agricultural University, Lublin, Poland.
PMID: 19642220 [PubMed – indexed for MEDLINE]
Bovine colostrum supplementation and exercise performance: potential mechanisms.
Sports Med. 2009;39(12):1033-54. doi: 10.2165/11317860-000000000-00000.Shing CM, Hunter DC,Stevenson LM.; School of Human Life Sciences, University of Tasmania, Launceston, Tasmania, Australia. Cecilia.Shing@utas.edu.au
Bovine colostrum supplementation attenuates the decrease of salivary lysozyme and enhances the recovery of neutrophil function after prolonged exercise.
Department of Sport and Exercise Science, Aberystwyth University, Carwyn James Building, Penglais Campus, Aberystwyth, Ceredigion SY23 3FD, UK; Davison G, Diment BC.
PMID: 20030905 [PubMed – as supplied by publisher]
Immune and hemorheological changes in Chronic Fatigue Syndrome.
J Transl Med. 2010 Jan 11;8(1):1; Brenu EW, Staines DR, Baskurt OK, Ashton KJ, Ramos SB, Christy RM, Marshall-Gradisnik SM.
ABSTRACT: BACKGROUND: Chronic Fatigue Syndrome (CFS) is a multifactorial disorder that affects various physiological systems including immune and neurological systems. The immune system has been substantially examined in CFS with equivocal results, however, little is known about the role of neutrophils and natural killer (NK) phenotypes in the pathomechanism of this disorder. Additionally, the role of erythrocyte rheological characteristics in CFS has not been fully expounded. The objective of this present study was to determine deficiencies in lymphocyte function and erythrocyte rheology in CFS patients. METHODS: Flow cytometric measurements were performed for neutrophil function, lymphocyte numbers, NK phenotypes (CD56dimCD16+ and CD56brightCD16-) and NK cytotoxic activity. Erythrocyte aggregation, deformability and fibrinogen levels were also assessed. RESULTS: CFS patients (n = 10) had significant decreases in neutrophil respiratory burst, NK cytotoxic activity and CD56brightCD16- NK phenotypes in comparison to healthy controls (n = 10). However, hemorheological characteristics, aggregation, deformability and fibrinogen, lymphocyte numbers and CD56dimCD16+ NK cells were similar between groups. CONCLUSION: Immune dysfunction may therefore be an important contributory factor to the mechanism of CFS, as indicated by decreases in neutrophil respiratory burst, NK cell activity and NK phenotypes. Thus, immune cell function and phenotypes are possible diagnostic markers for CFS.
PMID: 20064266 [PubMed – as supplied by publisher]
Improving fatigue assessment in immune-mediated neuropathies: the modified Rasch-built fatigue severity scale.
Van Nes SI, Vanhoutte EK, Faber CG, Garssen M, van Doorn PA, Merkies IS; PeriNomS Study Group; Bennett D, van den Berg LH, Van den Bergh PY,Cornblath DR, Dalakas M, Devigili G, van Doorn PA, Faber CG, Gorson KC, Hadden RD,Hahn AF, Hartung HP,Hughes RA, Lauria G, Léger JM, Lewis RA, Lunn MP, Merkies IS, Nobile-Orazio E,Notermans NC,Padua L, Reilly MM, >Smith B.; Department of Neurology, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands. firstname.lastname@example.org
Fatigue is a major disabling complaint in patients with immune-mediated neuropathies (IN). The 9-item fatigue severity scale (FSS) has been used to assess fatigue in these conditions, despite having limitations due to its classic ordinal construct. The aim was to improve fatigue assessment in IN through evaluation of the FSS using a modern clinimetric approach [Rasch unidimensional measurement model (RUMM2020)]. Included were 192 stable patients with Guillain-Barré syndrome (GBS), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) or polyneuropathy associated with monoclonal gammopathy of undetermined significance (MGUSP). The obtained FSS data were exposed to RUMM2020 model to investigate whether this scale would meet its expectations. Also, reliability and validity studies were performed. The original FSS did not meet the Rasch model expectations, primarily based on two misfitting items, one of these also showing bias towards the factor ‘walking independent.’ After removing these two items and collapsing the original 7-point Likert options to 4-point response categories for the remaining items, we succeeded in constructing a 7-item Rasch-built scale that fulfilled all requirements of unidimensionality, linearity, and rating scale model. Good reliability and validity were also obtained for the modified FSS scale. In conclusion, a 7-item linearly weighted Rasch-built modified FSS is presented for more proper assessment of fatigue in future studies in patients with immune-mediated neuropathies.
PMID: 20021568 [PubMed – in process]
Digestive Tract Disorders
Bovine colostrum prevents bacterial translocation in an intestinal ischemia/reperfusion-injured rat model.
J Med Food. 2009 Feb;12(1):37-46; Choi HS,Jung KH, Lee SC, Yim SV, Chung JH, Kim YW, Jeon WK, Hong HP,Ko YG, Kim CH, Jang KH, Kang SA.; Department of Emergency Medicine, Kohwang Medical Research Institute, Kyung Hee University, Seoul, Republic of Korea.
PMID: 19298194 [PubMed – indexed for MEDLINE]
Prebiotic effect of lacto-N-biose I on bifidobacterial growth.
Biosci Biotechnol Biochem. 2009 May;73(5):1175-9. Epub 2009 May 7; Kiyohara M, Tachizawa A, Nishimoto M, Kitaoka M, Ashida H, Yamamoto K.; Graduate School of Biostudies, Kyoto University, Kyoto, Japan. email@example.com
PMID: 19420691 [PubMed – indexed for MEDLINE]
Diet-dependent mucosal colonization and interleukin-1beta responses in preterm pigs susceptible to necrotizing enterocolitis.
J Pediatr Gastroenterol Nutr. 2009 Jul;49(1):90-8; Van Haver ER, Sangild PT,Oste M, Siggers JL; Department of Veterinary Medicine, University of Antwerp, Wilrijk, Belgium.
PMID: 19516189 [PubMed – indexed for MEDLINE]
The structural basis for the prevention of nonsteroidal antiinflammatory drug-induced gastrointestinal tract damage by the C-lobe of bovine colostrum lactoferrin.
Biophys J. 2009 Dec 16;97(12):3178-86; Mir R, Singh N,Vikram G, Kumar RP,Sinha M, Bhushan A, Kaur P, Srinivasan A, Sharma S, Singh TP; Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India.
Nonsteroidal antiinflammatory drugs (NSAIDs), due to their good efficacy in the treatment of pain, inflammation, and fever, are among the most prescribed class of medicines in the world. The main drawback of NSAIDs is that they induce gastric complications such as peptic ulceration and injury to the intestine. Four NSAIDs, indomethacin, diclofenac, aspirin, and ibuprofen were selected to induce gastropathy in mouse models. It was found that the addition of C-terminal half of bovine lactoferrin (C-lobe) reversed the NSAID-induced injuries to the extent of 47-70% whereas the coadministration of C-lobe prevented it significantly. The C-lobe was prepared proteolytically using serine proteases. The binding studies of C-lobe with NSAIDs showed that these compounds bind to C-lobe with affinities ranging from 2.6 to 4.8 x 10(-4) M. The complexes of C-lobe were prepared with the above four NSAIDs. All four complexes were crystallized and their detailed three-dimensional structures were determined using x-ray crystallographic method. The structures showed that all the four NSAID molecules bound to C-lobe at the newly identified ligand binding site in C-lobe that is formed involving two alpha-helices, alpha10 and alpha11. The ligand binding site is separated from the well known iron binding site by the longest and the most stable beta-strand, betaj, in the structure. Similar results were also obtained with the full length lactoferrin molecule. This novel, to our knowledge, binding site in C-lobe of lactoferrin shows a good complementarity for the acidic and lipophilic compounds such as NSAIDs. We believe this indicates that C-lobe of lactoferrin can be exploited for the prevention of NSAID-induced gastropathy.
Bovine colostrum promotes growth and migration of the human keratinocyte HaCaT cell line.
Growth Factors. 2009 Dec;27(6):448-55; Kovacs D, Cardinali G, Aspite N, Picardo M.; San Gallicano Dermatological Institute, IRCCS, Rome, Italy.
Mare’s colostrum globules stimulate fibroblast growth in vitro: a biochemical study.
J Med Food. 2009 Aug;12(4):836-45; Zava S, Barello C, Pessione A, Garoffo LP, Fattori P, Montorfano G, Conti A, Giunta C, Pessione E, Berra B, Giuffrida MG; Institute of General Physiology and Biological Chemistry, University of Milan, Milan, Turin, Italy.
PMID: 19735185 [PubMed – indexed for MEDLINE]
Bovine Colostrum: its dietary supplementation role in improvement and modulation of human immune indices
Nutrition and Food Science Department; Home Economics Faculty; Food Hygiene Department; National Institute of Nutrition; Cairo; Sherif S. Ragab and Effat A. A. Afif.
Oral ingestion of bovine colostrum lozenges student subjects has been shown to be effective in improvement and modulation of humoral and cell-mediated immune indices during the feeding (two weeks) and post-feeding (two weeks) duration’s. Both of circulate serum immunoglobulins IgG, IgM and IgA as a some parameters of humoral immunity and T-lymphocytes CD4 and CD8 as a some parameters of cell-mediated immunity in all of examined human subjects has been significantly influenced by oral supplementation by bovine colostrum lozenges. There was a direct positive correlation between the daily-received colostrum dose and the observed influence on the titters of measured immunity indices. A daily dose of 400 mg bovine colostrum supplementation has more improvement and increase effects on estimated parameters rather than 200 mg daily dose which indicate that the improvement and modulation roles of bovine colostrum supplementation on immunity status was carried out through a dose – dependant fashion. All of the student cases of this study were having a low to moderate levels of all measured immunity indices which improved and modulated significantly as a result of daily consumption of bovine colostrum supplement.
Factors associated with serum immunoglobulin levels in beef calves from Alberta and Saskatchewan and association between passive transfer and health outcomes.
Can Vet J. 2009 Mar;50(3):275-81; Waldner CL, Rosengren LB; Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4, Canada. firstname.lastname@example.org
PMID: 19436479 [PubMed – indexed for MEDLINE]
Enterocin C, a class IIb bacteriocin produced by E. faecalis C901, a strain isolated from human colostrum.
Int J Food Microbiol. 2009 Jul 31;133(1-2):105-12. Epub 2009 May 9; Caballero-Guerrero B, Jiménez E, Jiménez-Díaz R, Ruiz-Barba JL, Rodríguez JM; Departamento de Nutrición, Bromatología y Tecnología de Alimentos, Universidad Complutense de Madrid, Spain. email@example.com
PMID: 19501421 [PubMed – indexed for MEDLINE]
Seric and secretory antibodies reactive to alpha, beta and gamma intimins of Escherichia coli in healthy Brazilian adults.
FEMS Immunol Med Microbiol. 2009 Oct;57(1):32-9. Epub 2009 Jun 15; Zapata-Quintanilla LB, Tino-De-Franco M, Nuñez SP, Carbonare CB, Vulcano AB, Carbonare SB. Laboratório de Imunogenética, Instituto Butantan, São Paulo, SP, Brazil.
PMID: 19583778 [PubMed – indexed for MEDLINE]
A novel immunoregulatory protein in human colostrum, syntenin-1, for promoting the development of IgA-producing cells from cord blood B cells.
Int Immunol. 2009 Sep;21(9):1013-23. Epub 2009 Jul 10; Sira MM, Yoshida T, Takeuchi M, Kashiwayama Y, Futatani T, Kanegane H, Sasahara A, Ito Y, >Mizuguchi M, Imanaka T, Miyawaki T.; Department of Pediatrics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, Japan.
PMID: 19592421 [PubMed – indexed for MEDLINE]
Feeding heat-treated colostrum or unheated colostrum with two different bacterial concentrations to neonatal dairy calves.
J Dairy Sci. 2009 Sep;92(9):4565-71.; J Dairy Sci. 2009 Sep;92(9):4565-71; Elizondo-Salazar JA, Heinrichs AJ; Department of Dairy and Animal Science, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
PMID: 19700719 [PubMed – indexed for MEDLINE]
Bovine colostrum inhibits nuclear factor kappaB-mediated proinflammatory cytokine expression in intestinal epithelial cells.
Nutr Res. 2009 Apr;29(4):275-80; An MJ, Cheon JH, Kim SW, Park JJ, Moon CM, Han SY, Kim ES, Kim TI, Kim WH; Department of Internal Medicine and Institute of Gastroenterology, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.
PMID: 19410980 [PubMed – indexed for MEDLINE]
Pain & Fibromyalgia
Oral immunoglobulin induces mononuclear cell apoptosis in patients suffering from idiopathic chronic pain syndrome: results from a pilot study.
Int J Clin Pharmacol Ther. 2009 Jul;47(7):421-33; Gasser M, Stock M, Grimm M, Sprotte G.; Department of Surgery I, Molecular Oncology and Immunology, University of Wuerzburg, Germany.
PMID: 19640348 [PubMed – indexed for MEDLINE]
Leptin concentrations are a predictor of overweight reduction in a lifestyle intervention.
Int J Pediatr Obes. 2009;4(4):215-23; Reinehr T, Kleber M, de Sousa G, Andler W.; Vestische Hospital for Children and Adolescents, University of Witten/Herdecke, Datteln, Germany. T.Reinehr@kinderklinik-datteln.de
Leptin is essential in maintaining normal vascular compliance independent of body weight.
Int J Obes (Lond). 2009 Oct 6; Sikka G, Yang R, Reid S, Benjo A, Koitabashi N, Camara A, Baraban E, O’Donnell CP, Berkowitz DE, Barouch LA.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
PMID: 19806156 [PubMed – as supplied by publisher]
Methylnaltrexone potentiates body weight and fat reduction with leptin.
J Opioid Manag. 2009 Nov-Dec;5(6):373-8; Yuan CS, Sun S, Attele A, Wang CZ, Tong R, Israel RJ; Department of Anesthesia & Critical Care, Pritzker School of Medicine, University of Chicago, Illinois, USA
PMID: 20073411 [PubMed – in process]
Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation.
Cell Metab. 2010 Jan;11(1):77-83; Hayes MR, Skibicka KP, Leichner TM, Guarnieri DJ, DiLeone RJ, Bence KK, Grill HJ; University of Pennsylvania, Philadelphia, 19104, USA. firstname.lastname@example.org
Bringing evidence to complementary and alternative medicine in children with cancer: Focus on nutrition-related therapies.
Kelly KM; Pediatr Blood Cancer. 2008 Feb;50(2 Suppl):490-3; discussion 498; Division of Pediatric Oncology, Columbia University Medical Center, New York, New York, USA. email@example.com
PMID: 18064645 [PubMed – indexed for MEDLINE]
Therapeutic properties of proteins and peptides from colostrum and milk
Zimecki M, Artym J.; Zaklad Terapii Doswiadczalnej Instytutu Immunologii i Terapii Doswiadczalnej PAN im. Ludwika Hirszfelda we Wroclawiu. firstname.lastname@example.org
Colostrum and milk are rich in proteins and peptides which play a crucial role in innate immunity when transferred to the offspring and may accelerate maturation of the immune system in neonates. The immunotropic properties of these proteins prompted investigators research their potential application in prevention and therapy. Lactoferrin (LF) exhibits antibacterial, antifungal, antiviral, antiparasitice, and antitumoral activities. It is protective with regard to intestinal epithelium, promotes bone growth, and accelerates the recovery of immune system function in immunocompromised animals. LF was tried in the treatment of hepatitis C infection and the intestinal form of graft-versus-host disease (GvHD). A proline-rich polypeptide (PRP) demonstrated a variety of immunotropic functions, including the promotion of T-cell maturation and inhibition of autoimmune disorders. PRP, in the form of chewable tablets (Colostrinin) was recently found to improve or stabilize the health status of Alzheimer’s disease patients. Casein and casein-derived peptides showed protective activities in enamel demineralization and as caries-preventing agents. The protein hydrolyzates were also protective in diabetic animals, reduced tumor growth, had antihypertensive activity and diminished colicky symptoms in infants. Glycomacropeptide (GMP), a peptide derived from kappa-casein, exhibited various antibacterial and antithrombotic activities. Alpha-lactalbumin (LA) demonstrated antiviral, antitumoral and anti-stress properties. LA-enriched diets were anxiolytic, lowered blood pressure in rats, prevented diarrhea, and led to a better weight gain in malnourished children. HAMLET, a complex of LA and oleic acid, was effective in patients with cutaneous papillomas. Lysozyme found application in infant formulas, the treatment of periodentitis, and the prevention of tooth decay. Milk enriched in lysozyme was used in feeding premature infants suffering from concomitant diseases. Interesting, antibacterial properties were exhibited by lactoperoxidase. Both lysozyme and lactoperoxidase required cooperative action with LF in combating bacteria. In conclusion, preparations derived from milk and colostrum are effective, easily bioaccessible, and safe, finding wide application in prevention and therapy for newborns and adults.
PMID: 15995598 [PubMed – indexed for MEDLINE]